Dermal Fillers

Fight Signs of Facial Ageing. Reveal a younger-looking you!

Restylane® can be used to add volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds). Restylane may also be used for lip enhancement in patients over 21 years.

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What is Restylane?

The Restylane fillers offer a broad range of alternatives tailored for your individual needs. All products work to naturally enhance facial features, giving a long-lasting, yet non-permanent results.

The product in the Restylane fillers range can be used to smooth away wrinkles and fine line, create fuller and more accentuated lips, and adding facial volume and contour. Whatever your needs are, there’s a treatment that gives the best possible results.

The Restylane line of products is formulated to act like your body’s own naturally occurring hyaluronic acid, restoring volume to your skin.

All Restylane information sourced from restylaneusa.com.

How skin ageing works

It’s a part of life — our skin changes as we age. It becomes thinner, loses fat, and no longer looks as plump and smooth as it once did. Facial aging actually begins in your 20s, when skin firmness begins to decrease as a result of both internal (genetics and natural aging) and external (sun exposure, smoking, stress, etc.) factors.

What happens as we age?

• Hyaluronic acid is a naturally occurring substance in your skin that helps provide fullness and elasticity

• Hyaluronic acid diminishes as we age, causing skin to lose volume while increasing the chances for wrinkles and folds to appear

What can you do to help combat the signs of ageing

The good news is that you can do something about the signs of facial aging with a product in the Restylane family — to help reveal a younger-looking you.

Products in the Restylane family are used to:

• Provide natural-looking results by smoothing away facial wrinkles and folds and adding volume to lips (Restylane)

• Provide subtle lip enhancement and smoothing the lines around them (Restylane Silk)

• Add lift and volume to the cheeks and facial wrinkles and folds (Restylane Lyft)

• Provide natural-looking results to laugh lines with flexibility that allows you to maintain your natural expressions (Restylane Refyne & Restylane Defyne)

That means you get minimally invasive, clinically proven, natural-looking results to help achieve the look you want. Talk to your doctor at Divine Medical & Cosmetic Skin Centre today to determine if the Restylane family of products is right for you.

What to expect from treatment

Treatment with a product from the Restylane® family typically takes less than one hour. (Individual treatment times may vary.) Generally, there is minimal downtime associated with treatment using the Restylane family of products.

• Talk to your healthcare professional about options to make you as comfortable as possible during the procedure, including Restylane-L and pain medication.

• Your healthcare professional will cleanse and prepare the area(s) to be treated.

• The clear gel in the Restylane family of products is injected into the treatment area(s) using an ultra-fine needle to create the desired aesthetic effect.

Restylane Treatments

Restylane Restore

Restylane Fynesse
Fills fine lines and provides the skin with a smooth result.

Restylane Refyne
Fills lines and wrinkles and provides the skin with a refined result.

Restylane
Fills lines and wrinkles, providing more support and structure to the skin.

Restylane Volyme
Provides natural volumisation, restoring age related volume loss.

Restylane Enhance

Restylane Defyne
Shaping and defining facial contours through high lifting capabilities with a defined result.

Restylane Lyft
Providing lift and structure to the facial contours through high lifting capabilities with a pronounced effect.

Restylane Kysse
Enhancing the shape of the lip by adding volume and contour to the lip with a balanced and natural look.

Restylane Refresh

Restylane Skinboosters is a versatile and effective solution for skin concerns in the face, neck, décolletage and hands.

Natural Looking Results

With over 30 million treatments worldwide and counting, the Restylane line of hyaluronic acid fillers provides natural-looking results by smoothing away facial wrinkles and folds, providing subtle lip enhancement and smoothing the lines around the mouth, and adding lift and volume to the cheeks

Before & Afters

These images are unretouched photographs of real patients treated with Restylane injectable gel who received full correction in the lines from the nose to the corners of the mouth (nasolabial folds). Individual results may vary.

BEFORE / AFTER

Treated with 3 mL of Restylane in the smile lines (nasolabial folds). 4 weeks after treatment.

BEFORE / AFTER

Treated with 3 mL of Restylane in the smile lines (nasolabial folds).

BEFORE / AFTER

Treated with 3 mL of Restylane in the smile lines (nasolabial folds).

BEFORE / AFTER

Treated with 3 mL of Restylane in the smile lines (nasolabial folds).

BEFORE / AFTER

Treated with 3 mL of Restylane in the nasolabial folds, marionette lines, and upper lip, 3 mL of Restylane Lyft in the nasolabial folds and marionette lines. 4 weeks after treatment.

FAQ’s

The Restylane family of products is a brand of hyaluronic acid dermal fillers, which includes Restylane Silk, Restylane LyftRestylane, Restylane Refyne and Restylane Defyne. Each is a clear gel formulation of hyaluronic acid specifically formulated to act like your body’s own naturally produced hyaluronic acid. Each Restylane product is designed for a specific purpose.1

Restylane Silk is the first FDA-approved product specifically designed for subtle lip augmentation and the smoothing of wrinkles around the mouth. It is composed of a gel that is smaller and smoother than other Restylane products, resulting in a softer, more precise result — ideal for restoring and enhancing the lips. Additionally, Silk is administered via ultrafine needle, which is designed for improved accuracy and precision.

Restylane Lyft is approved for cheek augmentation and the correction of age-related midface contour deficiencies, as well as the treatment of moderate to severe facial folds, such as the nasolabial folds (smile lines). Lyft is the first and only FDA-approved filler with the ability to provide fullness to the cheeks, as well as restore lost volume in the midface area. Lyft contains 0.3% lidocaine, which is added to reduce the discomfort during treatment.

Restylane is used to add volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds). Restylane is also indicated for lip augmentation.

Restylane Refyne integrates with your skin to help smooth out the lines that run alongside the corners of your mouth (nasolabial folds and marionette lines)2and the flexibility you need for natural-looking movement and expressions.3,4

Restylane Defyne is designed to act like your body’s own hyaluronic acid to help smooth out deeper lines around your mouth (nasolabial folds and marionette lines)2 while letting you look more natural through a range of facial expressions.5

Restylane products are approved only for patients over the age of 21.

*XpresHAn Technology is known as Optimal Balance Technology outside the US. Restylane Refyne is known as Emervel® Classic and Restylane Defyne is known as Emervel® Deep outside the US.

Dermal fillers are facial injection treatments used to help diminish wrinkles while restoring volume and fullness in the face. There are several types of dermal fillers, one being hyaluronic acid. All Restylane products are transparent hyaluronic acids, which are sugars naturally found in the skin that help provide hydration, fullness and elasticity.

Wrinkles are part of life — our skin changes as we age. It becomes thinner, loses fat, and no longer looks as plump and smooth as it once did. Facial aging actually begins in your 20s, when skin firmness begins to decrease as a result of both internal (genetics and natural aging) and external (sun exposure, smoking, stress, etc.) factors.6

WHAT HAPPENS AS WE AGE?

  • Hyaluronic acid is a naturally occurring substance in your skin that helps provide fullness and elasticity, with the help of collagen and elastin.
  • Hyaluronic acid, collagen, and elastin diminish as we age, causing skin to lose volume, while increasing the chances for wrinkles and folds to appear

The “cupid’s bow” is the double curve of the upper lip, resembling the bow of Cupid, Roman god of love. The upper lip is believed to be most attractive when it is well-defined and when the two sides look the same. Everyone’s facial structure is different, and so is everyone’s ideal lip shape and size. Restylane Silk is designed to provide precise lip shaping and line control, resulting in silkier, smoother lips and natural-looking results.

With full treatment, you can see lasting results for up to 18 months with Restylane;9* up to 12 months in the cheeks and up to 6 months in facial wrinkles and folds, such as nasolabial folds, with Restylane Lyft;7 6 months with Restylane Silk;11 and up to 12 months in the facial wrinkles and folds (such as nasolabial folds and marionette lines) with Restylane Refyne and Restylane Defyne.7,8

Restylane Silk: In clinical studies, the results of Restylane Silk lasted approximately 6 months following treatment. In a U.S. clinical trial involving 221 mostly female subjects, 98% of subjects reported a visible improvement in lip fullness in upper and lower lip (combined) 14 days after injection, and 77% still had lip improvement at 6 months following injection.11

Restylane Lyft: In a clinical trial involving 200 subjects, investigators observed that 90% of subjects treated with Restylane Lyft showed an improvement in fullness in the right and left midface areas (combined) at 2 months, and 54% of subjects showed an improvement at 12 months. Additionally, 95% of subjects reported that they were satisfied with the appearance of their midface at 2 months, and 73% of subjects were satisfied at 12 months.10

Restylane: In a clinical study treating the lines from the nose to the corners of the mouth (laugh lines), blinded evaluators reported that 95% of subjects improved for up to 18 months when they received an initial Restylane treatment, plus a follow-up treatment approximately 4.5 or 9 months later. Using this Restylaneregimen of treatments, blinded evaluators reported similar subject improvement, on average, at 18 months compared to their Week 2 Wrinkle Severity Rating Scale (WSRS) score.9

Restylane Refyne & Restylane Defyne: In a clinical study of subjects treated for laugh lines with Restylane Refyne and Restylane Defyne, investigators reported improvement in the appearance of wrinkles for up to 12 months in the majority of patients. Using the Wrinkle Severity Rating Scale (WSRS), a validated 5-point measure of the size and depth of the wrinkles, with grade 1 defined as absence of wrinkles and grade 5 as extremely deep and long wrinkles, investigators reported that 79% of Restylane Refyne subjects and 77% of Restylane Defynesubjects had at least a 1-grade improvement on the WSRS after 6 weeks. Subjects also performed self-assessments (SSA) of wrinkle severity, with most reporting at least a 1-grade improvement in SSA scores with Restylane Refyne and with Restylane Defyne after 6 weeks.7,13,14

* The duration of effectiveness of Restylane for the correction of nasolabial folds (NLFs) was evaluated in a randomized, evaluator-blinded multicenter study. Restylane was shown to have an overall duration of effectiveness of 18 months from baseline following retreatment at 4.5 or 9 months.

Depending on your volume needs, most Restylane treatment appointments last less than an hour and begin to work almost immediately by adding volume to smooth away wrinkles. A clear gel formulation of hyaluronic acid, Restylane products act like your body’s own hyaluronic acid (and eventually break down naturally). Each Restylane product is designed for a specific purpose.

There are several factors that figure into how much treatment will cost, including:

  • Number of treatment sessions needed
  • Amount of Restylane product used per session
  • Degree of necessary correction determined by you and your specialist
  • Specialist fees
  • Discounts and special offers
  • Geographic market

Since injection costs will vary from person to person, the best way to determine projected costs is to book a no obligation consultation with Divine Medical.

After your treatment, you may experience side effects, such as swelling, redness, pain, bruising, headache and itching at injection site and tenderness. These are typically mild in severity and normally last less than 7 days in nasolabial folds and less than 14-18 days in lips. Patients should be limited to 6.0 mL per treatment of moderate to severe facial wrinkles and folds. Swelling may be more likely in patients under 36 years, and bruising may be more likely in patients over 35 years. Please see below for Important Safety Considerations for the Restylane family of products.

Initial Restylane treatments are usually complete in one or two sessions, as needed. Depending on your individual body chemistry, you will work with your specialist to determine a maintenance schedule. Talk to your physician or healthcare professional about your individual needs.

You can only receive Restylane products from a trained specialist. Restylane SilkRestylane LyftRestylaneRestylane Refyne and Restylane Defyne are administered by a physician or qualified healthcare professional.

The Restylane family of products should not be used by people who:

  • Are pregnant, breastfeeding, or under 22 years of age
  • Have recently used drugs that thin the blood or prevent clotting
  • Have had previous bad allergies, particularly to microorganisms known as gram-positive bacteria
  • Have serious allergies to drugs that have previously required in-hospital treatment
  • Have bleeding disorders
  • Have a known allergy to lidocaine, if using Restylane SilkRestylane lyftRestylaneRestylane Refyne or Restylane Defyne

The Restylane family of products includes Restylane®, Restylane-L®, Restylane® Lyft with Lidocaine, Restylane® Silk, Restylane® Refyne, and Restylane® Defyne.

APPROVED USES
Restylane® and Restylane-L® are for mid-to-deep injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds. Restylane® and Restylane-L® are also indicated for injection into the lips in patients over the age of 21.

Restylane® Lyft with Lidocaine is for deep implantation into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds and for cheek augmentation and for the correction of age-related midface contour deficiencies in patients over the age of 21.

Restylane® Silk is for lip augmentation and for correction of perioral wrinkles in patients over the age of 21.

Restylane® Refyne is for mid-to-deep injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds, in patients over the age of 21.

Restylane® Defyne is for mid-to-deep injection into the facial tissue for the correction of moderate to severe deep facial wrinkles and folds, such as nasolabial folds, in patients over the age of 21.

Are there any reasons why I should not use products within the Restylane® family? (Contraindications)

To ensure a safe procedure, your doctor will talk to you about your medical history to determine if you are an appropriate candidate for treatment. You should not use products within the Restylane family if:

  • You have severe allergies with a history of severe reactions (anaphylaxis)
  • You are allergic to lidocaine or to any of the gram-positive bacterial proteins used to make hyaluronic acid
  • You are prone to bleeding or have been diagnosed with a bleeding disorder

Are there other precautions that I should discuss with my doctor?

  • Tell your doctor if you are breastfeeding, pregnant, or trying to become pregnant. The safety of these products for use during pregnancy, or in women who are breastfeeding, has not been studied
  • Restylane, Restylane-L, Restylane® Lyft with Lidocaine, Restylane Refyne and Restylane Defyne are intended to treat facial wrinkles and folds, such as nasolabial folds.Restylane and Restylane-L are also intended for lip enhancement. Treatments in other areas of the face have not been evaluated in clinical studies.
  • The safety and effectiveness of Restylane® Silk for areas other than the lips and perioral area have not been evaluated in clinical studies
  • Tell your doctor if you have any history of scarring, particularly thick and stiff scars, or any pigmentation (skin color) disorders. These side effects can occur with hyaluronic acid fillers in general.
  • Tell your doctor if you are planning other laser treatments or a chemical peel, as there is a possible risk of inflammation at the treatment site if these procedures are performed after treatment
  • Patients who experience skin injury near the site of injection with these products may be at a higher risk for side effects
  • Tell your doctor if you are on any medications to decrease your body’s immune response (immunosuppressive therapy). Using these medications may increase your risk of bruising or bleeding at the gel injection site.
  • Tell your doctor if you are using any “blood thinners” such as aspirin, warfarin, or any other medications that affect bleeding. Using these medications may increase your risk of bruising or bleeding at the gel injection site.
  • The use of these products on gel injection sites with skin sores, pimples, rashes, hives, cysts, or infections should be postponed until healing is complete. Use of product in these areas could delay healing or make your skin problems worse.

What are the possible side effects?

The most commonly observed side effects are swelling, redness, pain, bruising, headache, tenderness, lump formation, and itching at the injection site. These are typically mild in severity and typically resolve in less than 7 days in nasolabial folds and less than 14 days in lips. Serious but rare side effects include delayed onset infections, recurrence of herpetic eruptions, and superficial necrosis at the injection site.

One of the risks with using this product is unintentional injection into a blood vessel. The chances of this happening are very small, but if it does happen, the complications can be serious, and may be permanent. These complications, which have been reported for facial injections, can include vision abnormalities, blindness, stroke, temporary scabs, or permanent scarring of the skin.

As with all skin injection procedures, there is a risk of infection.

To report a side effect with any of the Restylane products, please call Galderma Laboratories, L.P at 1-855-425-8722.

The Restylane family of products is available only through a licensed practitioner. View Complete Instructions for Use.

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